Aging is the main theme of this medical V-Learning™ lecture. Aging is defined as a gradual downfall in the physiological characteristics of an individual. Important concepts coming under the term aging include biological aging along with cellular senescence and organismal aging. There are two syndromes which resemble progerias viz Werner syndrome and Hutchinson-Guilford Progeria Syndrome. In the end, insulin and IGF-I signaling together with mTOR signalling are discussed in detail.
Lecture Duration: 01:13:54
Released: September 2019
Aging is a time-related decline in the bodily functions which are required for survival. The biological aging includes the deterioration of organ-system functions. This includes glomerular filtration, vital capacity alongside cardiac contractility. Antagonist pleiotropy is when one gene is responsible for more than one trait. It includes hyperfunctioning and intestine atrophy.
The cellular senescence and organismal aging involve the absence of molecular markers of proliferation. A very crucial underlying mechanism, in aging, is the telomere shortening. The other important topic covered in this lecture is the senescence-associated secretory phenotype (SASP).
Reactive oxygen species (ROS) are responsible for causing certain age-related diseases along with causing oxidative damage. Amongst the role of telomere, both the capped and uncapped telomere are brought under consideration. Senescence can ultimately cause Cancer and mitochondrial function decline.
Two syndromes which resemble accelerated aging or progerias include Werner syndrome and Hutchinson-Guilford Progeria Syndrome. Furthermore, defects in DNA repair in conjunction with hormesis, insulin and IGF-I signaling are delineated. In addition to this, mTOR signaling and role of sirtuins are explicated.
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sqadia.com V-learning™ provides you pathology lectures by Doctors and expert clinical pathologists. Aim is to make modern medical student learning easy and provide video medical lectures according to standard syllabus of MBBS and other medical sciences. Standard and Reference books of pathology are followed e.g. “Rubin’s Pathology – Clinicopathologic Foundations of Medicine” by David S. Strayer.